POLYNUCLEOTIDES York | York's Leading Clinic For POLYNUCLEOTIDE Injections

Here at Michelle Orman Aesthetics, we offer advanced polynucleotide-based injectable treatments, including Vitaran and Plenhyage, designed to repair and regenerate the skin at a cellular level. Derived from purified DNA fragments, polynucleotides act as bio-stimulators—triggering natural healing responses, improving skin quality, and restoring tissue structure from within.

 

Unlike traditional fillers or boosters, polynucleotides focus on true regeneration, supporting fibroblast activity, increasing collagen and elastin production, and enhancing skin hydration, elasticity, and tone.


Vitaran is a high-purity polynucleotide formulation designed for hydration, skin quality improvement, and dermal healing—especially effective in treating sensitive or reactive skin.



Plenhyage offers a more structured approach to tissue regeneration and is particularly suited for volume-deficient or photo-damaged skin, delivering visible improvement in firmness and resilience.

About Polynucleotides:

Please Note: All results may vary from client to client

Vitaran: recommended a course of 2 to 3 treatments spaced 2 to 4 weeks apart is recommended, followed by maintenance treatments every 6–12 months, depending on individual skin needs

PLenhyage: recommended a course of 2 sessions spaced 4 weeks apart is recommended, followed by maintenance treatments every 6–9 months, depending on individual skin needs.

BENEFITS OF POLYNUCLEOTIDE THERAPY

  • Improves skin texture, firmness, and hydration
  • Reduces fine lines, wrinkles, and superficial scarring
  • Strengthens the skin barrier and reduces inflammation
  • Ideal for delicate areas such as the under-eye, neck, and décolletage
  • Safe for most skin types, with long-lasting regenerative effects

Prices
Vitaran Face or Neck 1 session - £200

Vitaran Face or Neck 2 sessions - £300

Vitaran Face or Neck 3 sessions - £400

 

Vitaran under eyes 1 session - £160

Vitaran under eyes 2 sessions - £260

Vitaran under eyes 3 sessions - £360

 

Plenhyage XL 1 session - £250

Plenhyage XL 2 sessions - £450

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WHAT CAN WE TREAT WITH ANTI-WRINKLE INJECTIONS

• Frown lines

• Crows feet

• Bunny lines

• Glabellar lines

• Gummy Smile

• Forehead line

Prices
From £170

*Consultation required with our nurse prescriber in advance of treatment to check suitability

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FAQs

Got a question? We’re here to help.

  • What is the difference between Polynucleotides and Skin Boosters?

    While both Skin Boosters and Polynucleotides are injectable treatments used in aesthetic medicine, they work in slightly different ways and are designed to address different concerns. Skin Boosters primarily focus on skin hydration and firmness, while Polynucleotides stimulate collagen production and improves overall skin health. The products are not the same but can be combined.

  • What is the difference between Polynucleotides and Dermal Fillers?

    Despite there being different types of dermal filler, the most well-known and perhaps the most popular types are hyaluronic acid (HA) fillers.The biggest difference between the two injectables is that hyaluronic acid dermal fillers work by restoring and adding volume to the skin. With dermal fillers, the results are almost instantaneous with visible contouring and augmentation – often lasting up to 18 months depending on the type of dermal filler used.On the other hand, polynucleotides work to stimulate fibroblasts at a cellular level to improve skin health. Contrarily to hyaluronic acid dermal fillers, whilst polynucleotides can add slight volume to the injected area, their main goal is rejuvenation.


    These injections have no direct effects on the muscle, as they affect the proteins within the nerve endings. During this process, these nerve endings rebuild straight away and will regain normal function in roughly 3-4 months time. The primary aim of anti-wrinkle injections is to weaken the muscles that create undesired facial expressions.


    The continual use of anti-wrinkle injections makes these muscles smaller, reducing the number and frequency of treatments that you will need over time.

  • Who Should Not Have Polynucleotide Treatments?

    While the treatments are very safe, there are several contraindications that both clients and clinics should be aware of. 


    Polynucleotides are not recommended for individuals who:


    • Have fish allergies – Polynucleotide treatments should not be given to clients with fish allergies. This is because they are derived from fish, which could cause allergic reactions. 

    • Are pregnant or breastfeeding – These treatments are not suitable for individuals who are pregnant, breastfeeding, or undergoing IVF treatment. 

    • Have active skin conditions – Polynucleotide treatments should not be injected in any area where there is an active skin condition or infection.